• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention relates to the use of an aloe compound, whether as a nutraceutical or a pharmaceutical compound, as an effective ingredient for hair treatment, aging and other derivative applications. The products used so far for this purpose are of topical use and require repeated applications, often cumbersome. The objective of the present invention is a new use of an oral intake compound, with excellent activity against the appearance of gray hair, prevention of hair loss and improvement in its general appearance, as well as other manifestations of aging. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2581180A1
    申请号:ES201500700
    申请日:2015-09-10
    公开日:2016-09-01
    发明作者:Yeray BRITO CASILLAS；Ana María WÄGNER
    申请人:Universidad de las Palmas de Gran Canaria；
    IPC主号:
    专利说明:

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    DESCRIPTION
    Use of oral aloe for hair enhancement.
    The present description refers to a new use of oral aloe compounds as effective ingredients for hair treatment, aging and other derived applications.
    An objective of the present invention is to provide a new use for an oral intake compound, with an excellent activity against the appearance of gray hair, prevention of hair broth and improvement in its general appearance.
    More specifically, the present description refers to the use of a compound to generate one or more oral, powdered, encapsulated, dragee or other presentations or added as an ingredient directly in liquid or solid foods, for patient use, public consumer or animals
    State of the prior art
    Aloe vera, known as sabila, savila, Barbados aloe or Curacao aloe, among others, is a succulent plant of the Asphodeloideae subfamily within the Xanthorrhoeaceae family. It contains more than 500 species of succulent plants, of which aloe vera is probably the best known, for the many properties attributed to it.
    Two substances used for medicinal purposes are derived from aloe: gel and latex. The gel is a transparent, jelly-like substance found in the pulp of the leaves and the latex is yellow and is extracted from under the skin of the plant. Some aloe products are made from the whole and crushed leaf, so that they contain both the gel and the latex (https: / l www.nlm.nih.gov/medlineplus/spanish/druginfo/natura//607.html).
    Today, topical use of aloe predominates, as a remedy for skin conditions that include burns, psoriasis and cold sores, or to promote the healing of bedsores and wounds.
    Some chemical substances are known in the aloe gel that seem to be able to increase the circulation in the small blood vessels in the skin and also kill the bacteria. These effects suggest that aloe gel may be effective in accelerating wound healing.
    Aloe latex by mouth is usually used for constipation. Less often, aloe latex is used orally for epilepsy, asthma, colds, blood loss, amenorrhea, colitis, depression, diabetes, multiple sclerosis, hemorrhoids, varicose veins, Bursitis, osteoarthritis, glaucoma and other vision problems.
    But taking aloe latex by mouth is probably not safe, especially at high doses. There is some concern that some of the chemical substances found in aloe latex could cause cancer. In addition, aloe latex can cause kidney problems and could lead to serious kidney problems and even cause death.
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    (, https .// www.nlm.nih.gov/medlineplus/spanish/druginfo/natura/607.html)
    Therefore, science shows the efficacy of aloe in psoriasis when a cream containing 0.5% of aloe is applied to the skin and used for four weeks, a decrease in the "plaques" in the skin associated with psoriasis is observed. And, in constipation, lomar latex of aloe by mouth can decrease constipation and cause diarrhea
    (https.//lwww. nlm. nih.gov/medlineplus/spanish/druginfo/natura/607. html)
    As for the patented rescued compounds that include aloe, either as a main or minor component, with cosmetic or medicinal applications on skin and hair, the topical route has been used in the patents, JP2012197240A, US2014134261A1, JP3966922B2, JP2000143527A, JP3632347B2, JP2007332109A , EP0919220A2, JP2007169206A.
    Uses, products, previous compounds related to the new invention:
    JPH01290617A: Drink consisting of soba, citric acid and crushed aloe leaves, which is proposed to promote hair growth, not to improve hair appearance and aging, which is the invention that concerns us.
    JP3932781B2: Aloe arborescens juice, prepared hot from whole leaves, which has been proposed for multiple applications, orally: for anti-aging and prevention of baldness, as well as for the treatment of insect burns and bites, in this invention it is not specified, and the topical route is deduced.
    JP3932781B2: Form of preparation of the whole aloe leaf, by crushing, mixing with water and application of heat and pressure, other than that proposed in the present invention, which has claimed anti-aging effects in the list of potential applications Although It is not specified in the patent document, the topical route is deduced.
    JP2012197240A: Mixture of ingredients that includes aloe, in addition to another 6, for the prevention of gray hair. The increase in melanin production is claimed by melanocytes, which has been demonstrated in vitro. They do not show in vivo studies. In addition, the product of said patent is classified as cosmetic (A61P17 / 00) of topical application (A61Q5 / 00).
    JP2007332109A and JP2007169206A Hair tonic, contain aloe and other ingredients, claim the treatment of gray hair and hair broth, topical application.
    The present invention, which is intended to be protected, proposes the use of freeze-dried aloe, without additives, orally, for the prevention and treatment of gray hair, hair broth and other manifestations of aging, in addition to improving the appearance of hair , unlike previous forms of preparation that include extracts with organic solvents (JP2000143527A) or water and heat application (JP3932781B2), filtered and pressed or are of topical application (see above).
    JP3932781B2, FUKAZAWA SHINJI.
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    JP2012197240A,, SS PHARM CO US2014134261A1,, TRINJTY LAB INC JP3966922B2,, ICHIMARU PHARCOS INC JP2000143527A,, NOEVIR KK
    JP3632347B2,, KANEBO COSMETICS INC (KANE) KANEBO LTD JP2012197240A,, SS PHARM CO,
    JP2007332109A,, YANAGI AND EP0919220A2,, LlZZI J JP2007169206A,, MATSUMURA T
    Although in some cases the previous inventions propose the use of aloe for applications similar to those we propose with the new invention, it should be noted that the composition of the invention described, used orally, provides a notable improvement in hair , delayed hair aging and improved appearance.
    Another relevant application could be the treatment of young people with high predisposition to the premature appearance of gray hair (premature graying-hair, PGH), whose incidence is located in some study in 1.2% of high school and university students. This process generates an important psychological impact on these young people. It is a persistent alteration, whose only solution is periodic hair staining.
    Therefore, there is a need for a compound that partially solves the disorders described above.
    Explanation of the invention
    Aloe has been used for multiple purposes, especially cosmetic, for which it is applied directly to the hair or skin. The present invention proposes the use of a freeze-dried compound of aloe, orally, for the improvement of the appearance and shine of the hair, including the delay in its broth and in the appearance of gray hair, as well! such as the delay of other manifestations of aging.
    It is a preparation without organic solvents or other additives, which increases its safety for oral administration.
    It can be used directly, encapsulated, in the form of dragees or other presentations, or mixed with other active ingredients or in food or drink. Its human and animal use is contemplated, in this case, for example, mixed or incorporated into the feed to improve the health and appearance of the coat.
    The preparation is obtained from extracts of the aloe leaf, obtained without the use of heat or organic solvents.
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    The invention originates from the observation, from its administration to diabetic C57BI / 6J mice induced by fat diet, of advanced age, which demonstrated a delay in the appearance of gray hair as well as in its extension by the body surface. They also showed a delay in the appearance of areas of alopecia (bald) and other signs of aging compared to those who received food without this component. Likewise, treated mice showed a brighter and healthier coat than untreated mice.
    Detailed Description
    The compound may comprise:
    • Lyophilisate of aloe, as the main or major component (20-100%) in a compound administered orally in the form of dragees, capsules or other presentations or added to the diet (liquid or solid), so as to ensure a daily dose ingested between 0.1-5 g / kg of the product.
    Thus, through this component, the appearance of the hair is improved, its broth and the appearance of gray hair are prevented, without requiring any type of medication or similar. In addition, the appearance of other manifestations of aging is delayed.
    1. Compound, orally, to generate one or more hair enhancements, including, but not limited to prevention in the broth and appearance of gray hair and delayed signs of aging of people and animals, characterized by the fact that the compound comprises lyophilized of aloe in 20-100% of its composition, or derivative thereof.
    2. A nutraceutical composition according to revindication 1, in the form of an oral formulation:
    - liquid or solid,
    - pulverization or fine powder,
    - food additive,
    - I think, premix or supplement to incorporate into animal feed.
    3. A compound, according to revindication 1, pharmaceutically acceptable thereof, for use as a pharmaceutical product for humans or for non-human animals.
    4. According to revindication 1 and 2, a pharmaceutical composition for the treatment or prevention of capillary improvements, delayed signs of aging of people and animals, comprising a therapeutically effective amount of a compound together with a pharmaceutically acceptable vehicle.
    5. Composite product according to revindication 1, 2, 3, 4 in which its use is for one or more hair enhancements, delayed signs of aging of individuals and animals applications.
    6. Composite product according to revindication 1, 2, 3, 4 in which its use is for one or more prevention of signs of aging of individuals and animals.
    Detailed exposition of realization modes
    For example, from the aloe leaf, a fried extract is obtained, without organic solvents or additives, which is subsequently lyophilized. Said lyophilisate is used at 5 doses of 0.1-5 g / kg in order to improve the appearance of the hair, prevent its broth and delay other manifestations of aging, as demonstrated in the strain of mice studied
    权利要求:
    Claims (3)
    [1]
    1. Use of a compound orally, which comprises aloe in 20-100% of its composition, to generate hair improvements, included, but not limited to prevention
    5 and treatment of gray hair and alopecia, in humans and animals.
    [2]
    2. Medication (pharmaceutical composition) for humans and animals, which contains aloe in 20-100% of its composition.
    10 3. Medication (pharmaceutical composition) for humans and animals, which
    administered at a dose of 0.1-5 g / kg of aloe.
    [4]
    4. Medication according to claim 2 or 3 for the prevention and treatment of gray hair.
    15 5. Medication according to claim 2 or 3 for the prevention and treatment of
    alopecia.
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    同族专利:
    公开号 | 公开日
    ES2581180B1|2017-07-07|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    KR20040042553A|2002-11-15|2004-05-20|최창원|Compositions of hebal extracts and pharmaceutical compositions for preventing lose of hair and promoting growth of hair|
    CN101288635A|2008-05-04|2008-10-22|王跃进|Natural back hair antidandruff shampoo|
    JP2013144650A|2012-01-13|2013-07-25|Kobayashi Pharmaceutical Co Ltd|Vegf production promoter|
    CN103783504A|2013-09-27|2014-05-14|钟跃平|Aloe lozenges and preparation method thereof|
    CN104306947A|2014-11-13|2015-01-28|天津春花秋月科技发展有限公司|Black hair regenerating solution|WO2021037322A1|2019-08-27|2021-03-04|Portillo Rosado Rosa Maria|Composition for delaying and dyeing grey hair|
    法律状态:
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    优先权:
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    ES201500700A|ES2581180B1|2015-09-10|2015-09-10|USE OF ORAL ALOE FOR HAIR IMPROVEMENT|ES201500700A| ES2581180B1|2015-09-10|2015-09-10|USE OF ORAL ALOE FOR HAIR IMPROVEMENT|
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